This is an application from the University Of Pennsylvania Perelman School Of Medicine and the Children's Hospital of Philadelphia to continue their participation as a Clinical Center in the Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network (NRN). The NRN performs experimental and observational clinical studies in sick and preterm newborn infants. The goal of the Network is to advance neonatal care and improve long-term outcomes through rigorous evaluation using common protocols.